http://schca-ir.schmc.ac.kr/handle/2022.oak/1318 2026-10-22T23:00:39Z 2026-10-22T23:00:39Z 김서영 전용호 권영준 정희연 황보영 심세훈 http://schca-ir.schmc.ac.kr/handle/2022.oak/4603 2024-08-20T05:20:12Z 2006-12-31T15:00:00Z

Title: 남자 정신분열병 환자의 소뇌기능과 정신증상 및 인지기능간의 연관성 All Author(s): 김서영; 전용호; 권영준; 정희연; 황보영; 심세훈 Abstract: Objectives:There is increasing evidence that the cerebellum plays an important role in cognition and psychiatric symptoms as well as motor coordination. The concept of cognitive dysmetria has been making cerebellar function in schizophrenia the focus of current studies. In other words, disruption in the corticocerebellum-thalamic -cortical circuit could lead to disordered cognition and clinical symptoms of schizophrenia. The purposes of this study were to determine cerebellar dysfunction in male schizophrenic patients semiquantitatively with ICARS and to investigate the clinical and cognitive correlates of ICARS in patients. Methods:We compared the scores of cerebellar neurologic sign using ICARS in 47 male patients with a DSM-IV-TR diagnosis of schizophrenia with 30 gender and age-matched healthy control subjects. The semiquantitative 100-point ICARS consists of 19 items divided into 4 unequally weighted subscores:posture and gait disturbances, kinetic functions, speech disorders and oculomotor disorders. All subjects were also assessed with cognitive function test. Cognitive functions were evaluated by Korean-Mini Mental Status Examination (K-MMSE), Verbal fluency test, and Clock drawing test. The patients were administered Korea version of Positive and Negative Symptom Scale(K-PANSS) to assess the symptom severity. Results:Schizophrenic patients had significantly higher scores on the ICARS than control subjects with posture and gait disturbances, kinetic functions, and oculomotor disorders. They also showed more significant impairments in cognitive function tests than control subjects. There was a significant correlation between ICARS and negative symptoms of patients. In cognitive function test, Clock drawing test was significantly associated with negative symptoms. In addition, Clock drawing test was negatively correlated with the total score of ICARS. Conclusion:In this study, we confirmed that schizophrenic patients have significant impairments in cognitive and cerebellar function, and that those were related with negative symptoms of schizophrenic patients. These results support a role of the cerebellum in schizophrenia. It is meaningful that we used a structured, and reliable procedure for rating neurological soft signs, ICARS. We hope that future prospective studies using a similar design help that rate of neurological sign should have been visible with the progression of illness.

2006-12-31T15:00:00Z 심세훈 황보영 권영준 정희연 이분희 김용구 http://schca-ir.schmc.ac.kr/handle/2022.oak/4605 2024-08-20T05:20:12Z 2007-12-31T15:00:00Z

Title: 우울장애 환자에서 자살 시도와 트립토판 수산화 효소(Tryptophan Hydroxylase) A218C 유전자 다형성과의 관련성 All Author(s): 심세훈; 황보영; 권영준; 정희연; 이분희; 김용구 Abstract: Objectives : Several lines of evidence suggest the serotonergic dysfunction involved in the biological susceptibility of suicide. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, plays a vital role in serotonin metabolism. In a case-control study, we investigated whether the TPH gene was a susceptible factor for suicidal behavior in depressive patients. Methods : The subjects were 218 depressed patients who attempted suicide and visited emergency rooms in multi-medical centers. One hundred thirty hospitalized non-suicidal depressed patients and the 161 normal controls were matched with the suicidal group. Individuals in all 3 groups were evaluated independently by a Structured Clinical Interview for the purpose of establishing a DSM-IV criteria diagnosis (SCID). The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS). Results : There was no significant difference in genotype distributions and allele frequencies of TPH intron 7 A218C polymorphisms among 3 groups. Furthermore, no significant difference in genotype counts and allele frequencies of the polymorphisms was found among lethal suicidal depressed patients, non-suicidal depressed patients and the normal controls. Conclusion : This study suggests that the A218C polymorphism of the TPH gene is unlikely to have a major effect on the susceptibility of suicidal behaviors in depressive patients.

2007-12-31T15:00:00Z I. K. Seo Y. I. Choi D. S. Jeong H. K. Park Y. Hwangbo K. I. Yang http://schca-ir.schmc.ac.kr/handle/2022.oak/4604 2024-08-20T05:20:12Z 2012-12-31T15:00:00Z

Title: 수면의 질과 비현훈어지럼 간의 연관성: 병원기반 환자-대조군 연구 All Author(s): I. K. Seo; Y. I. Choi; D. S. Jeong; H. K. Park; Y. Hwangbo; K. I. Yang Abstract: OBJECTIVES: Poor sleep quality can impair daytime function and evoke fatigue and excessive daytime sleepiness. Dizziness is one of the common subjective complaints and attributed to various medical and neuropsychological disorders. But influence of poor sleep quality on dizziness has not been fully studied. We hypothesized the patients with poor quality of sleep might feel non-vertiginous dizziness (NVD). The aim of this study is to investigate the association between sleep quality and development of NVD.

2012-12-31T15:00:00Z J. S. Gang H. S. Kim H. H. Bang T. H. Kim H. J. Lee Y. Hwangbo J. S. Park http://schca-ir.schmc.ac.kr/handle/2022.oak/4606 2026-10-05T08:12:06Z 2016-12-31T15:00:00Z

Title: 휴대용 에피네프린 처방률을 포함한 소아 아나필락시스의 연구 All Author(s): J. S. Gang; H. S. Kim; H. H. Bang; T. H. Kim; H. J. Lee; Y. Hwangbo; J. S. Park Abstract: Purpose: Anaphylaxis is an acute, life-threatening systemic reaction which should be treated by epinephrine, and patients should be prescribed epinephrine auto-injector after the event. The purpose of this study was to investigate the clinical features of pediatric anaphylaxis, including the rate of using epinephrine at hospital and prescribing epinephrine auto-injector. Methods: We performed a retrospective study of 68 anaphylactic patients at in-hospital, out-hospital, and Emergency Department of Soonchunhyang University Cheonan Hospital, Cheonan, Korea, who were under 15 years of age, from January 2013 through December 2014. We reviewed their clinical features, doctor's treatment methods, rate of follow-up and prescribing epinephrine autoinjectors. Results: Causes of anaphylaxis were food (76.5%), drug (10.3%), and idiopathic (13.2%). The involved organs were the skin (86.8%), respiratory tract (80.9%), cardiovascular system (23.5%), and gastrointestinal tract (17.7%). Patients were treated with systemic steroids (91.2%), antihistamines (88.2%), and epinephrine (75.0%). Fifty-three patients (77.9%) revisited our pediatric allergy clinic and epinephrine auto-injectors were prescribed for 25 patients (36.8%). Conclusion: Physicians should make an effort to use epinephrine as an initial treatment of anaphylaxis, to prescribe epinephrine auto-injectors, and to give proper information about disease.

2016-12-31T15:00:00Z